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Withings products not only help individuals and their clinicians better monitor and understand health, but they are contributing to a wide body of research. Withings is honored that researchers are increasingly turning to our products across an impressive number of therapeutic areas. Among them are diabetic neuropathy, retinopathy, sudomotor function, hypertension, sleep quality, sleep apnea, dementia, ECG intervals in children, arrhythmias, cardiovascular autonomic neuropathy (CAN), public health monitoring, and health technology adoption.
Here’s just a sampling of the diversity and reach of Withings products in medical research this year.
An October 2024 article in Frontiers in Neuroanatomy looks at the history and technical development of electrochemical skin conductance (ESC), as measured by Withings’ Sudoscan, and compares it to other measures of skin conductance such as galvanic skin response (GSR) and electrodermal activity (EDA). ESC was developed specifically to diagnose sudomotor function as opposed to GSR/EDA which is a continuous monitoring tool. EDA is increasingly incorporated into wearable technology. While both use skin/sweat conductance, it is important to differentiate EDA which can be used for physiological and psychological measures of stress from ESC which is used to evaluate sudomotor function and diagnose neuropathy. Withings has incorporated ESC in its smart scales which show a near perfect correlation with the Sudoscan clinical device. The Withings smart scales allow for easier and more frequent individual time series data as well as large scale data collection.
Public health surveillance has largely relied on self-reported surveys. This study applied mobile and wearable technologies to collect objective, real-time, continuous health data. Data from a variety of Withings products (Withings Sleep, Withings BPM Connect, Withings Thermo, and Withings Body+), were used to predict stress. Findings showed that a system, such as the Mobile Health Platform used here, could complement self-reported health data to better monitor and predict stress in a population.
This study compared the 1-lead ECG intervals available via the Withings ScanWatch with the standard 12-lead ECGs in children and adolescents. Smart watch intervals have previously been shown to be accurate for adults. The heart rate measure was found to be reliable for children, The automated QTc interval was less reliable but can be improved with manual measurements. It is worth noting that the study used pediatric subjects rather than adapting adult research, as is often the case.
This study of 67,254 adults showed that 30% of adults do not get the recommended 7-9 hours of sleep per night, and that even those who did average 7-9 hours, 40% of the nights fell outside the range. Only 15% of participants slept 7-9 hours for at least 5 nights per week. In addition to the findings of irregular sleep, the study highlights the usefulness of the at home Withings Sleep for large-scale and/or longitudinal sleep studies.
As we close out a year of significant knowledge advancements, we look forward to seeing what the global healthcare research community has in store for 2025.
If you are conducting research that might benefit from Withings technology, please contact us at contact-pro@withings.com.
Interested in partnering with us?
Contact Us
[post_title] => Withings 2024 Year in Review: Research Highlights
[post_excerpt] => 2024 was an exciting year for Withings. We’re honored that the global research community is increasingly turning to our solutions for studies across an impressive number of therapeutic areas. Among them are diabetic neuropathy, retinopathy, sudomotor function, hypertension, sleep quality, sleep apnea, dementia, ECG intervals in children, arrhythmias, cardiovascular autonomic neuropathy (CAN), public health monitoring, and health technology adoption.
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Several new, large-scale studies1, 2, 3, 4 from the Flinders Medical Research Institute (FHMRI) in Australia found studying sleep in real-world settings over multiple nights can greatly reduce the high 30% error rate of sleep apnea diagnosis from polysomnography (PSG), the traditional, single night, in hospital gold standard technique. Using Withings Sleep Analyzer, researchers were able to easily track multiple biomarkers for participants over time revealing large variability in sleep indicators from night to night.
Withings under-the-mattress sleep trackers have enabled researchers to study large groups over time. The FHMRI studies tracked 67,278 and 12,287 participants respectively over a total of 11 million nights, a feat not feasible with traditional polysomnography.
A key finding from the study of 12,000 users is the variability in the severity of Obstructive Sleep Apnea (OSA) from night to night. The variability of OSA, independent of severity, is associated with uncontrolled hypertension which is the leading cardiovascular risk factor. Sleep Analyzer also reveals other risks associated with hypertension, such as snoring, irregular waking and sleep hours, and duration of sleep.
Using the same hardware technology as Withings Sleep Analyzer, Sleep Rx is a noninvasive, at home device that users place under their mattresses to gather biomarkers such as heart rate, respiratory rate, snoring, sleep cycles, and the Withings Sleep Index, a measure of breathing events per hour, which can aid in the diagnosis of sleep apnea. Using this simple device for at least 14 nights gives a much clearer picture of sleep quality.
The multi-night Sleep Rx data can be used to predict the right patients at the right time for in hospital PSG. Better identification of patients who most need PSG will reduce overall spending on the costly tests and ease scheduling difficulties.
Sleep Rx offers an inexpensive, easy to use method to better target high risk cardiovascular patients, reduce the high error rate of sleep apnea diagnosis, and efficiently gather longitudinal, large-scale sleep data for a variety of chronic diseases. For more information about the Withings Sleep Rx, click here.
References
1 Lechat, Bastien et al. “Multinight Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea.” American journal of respiratory and critical care medicine vol. 205,5 (2022): 563-569. doi:10.1164/rccm.202107-1761OC
2 Lechat, Bastien et al. “High night-to-night variability in sleep apnea severity is associated with uncontrolled hypertension.” NPJ digital medicine vol. 6,1 57. 30 Mar. 2023, doi:10.1038/s41746-023-00801-2
3 Lechat, Bastien et al. “Regular snoring is associated with uncontrolled hypertension.” NPJ digital medicine vol. 7,1 38. 17 Feb. 2024, doi:10.1038/s41746-024-01026-7
4 Scott, Hannah et al. “Sleep Irregularity Is Associated With Hypertension: Findings From Over 2 Million Nights With a Large Global Population Sample.” Hypertension (Dallas, Tex. : 1979) vol. 80,5 (2023): 1117-1126. doi:10.1161/HYPERTENSIONAHA.122.20513
Interested in partnering with us?
Contact Us
[post_title] => Sleep Apnea Data from Multiple Nights is Key to Predicting Hypertension and Cardiovascular Risk
[post_excerpt] => New large-scale, longitudinal studies show that monitoring sleep for at least 14 nights at home with a connected sleep tracking mat, can reduce the 30% high error rate of sleep apnea diagnosis from the usual single-night, in hospital polysomnography (PSG) technique. This technology can identify which patients most need expensive, intrusive, and difficult to access PSG. Longitudinal data also detects variability of Obstructive Sleep Apnea from night to night which is associated with hypertension
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Withings products not only help individuals and their clinicians better monitor and understand health, but they are contributing to a wide body of research. Withings is honored that researchers are increasingly turning to our products across an impressive number of therapeutic areas. Among them are diabetic neuropathy, retinopathy, sudomotor function, hypertension, sleep quality, sleep apnea, dementia, ECG intervals in children, arrhythmias, cardiovascular autonomic neuropathy (CAN), public health monitoring, and health technology adoption.
Here’s just a sampling of the diversity and reach of Withings products in medical research this year.
An October 2024 article in Frontiers in Neuroanatomy looks at the history and technical development of electrochemical skin conductance (ESC), as measured by Withings’ Sudoscan, and compares it to other measures of skin conductance such as galvanic skin response (GSR) and electrodermal activity (EDA). ESC was developed specifically to diagnose sudomotor function as opposed to GSR/EDA which is a continuous monitoring tool. EDA is increasingly incorporated into wearable technology. While both use skin/sweat conductance, it is important to differentiate EDA which can be used for physiological and psychological measures of stress from ESC which is used to evaluate sudomotor function and diagnose neuropathy. Withings has incorporated ESC in its smart scales which show a near perfect correlation with the Sudoscan clinical device. The Withings smart scales allow for easier and more frequent individual time series data as well as large scale data collection.
Public health surveillance has largely relied on self-reported surveys. This study applied mobile and wearable technologies to collect objective, real-time, continuous health data. Data from a variety of Withings products (Withings Sleep, Withings BPM Connect, Withings Thermo, and Withings Body+), were used to predict stress. Findings showed that a system, such as the Mobile Health Platform used here, could complement self-reported health data to better monitor and predict stress in a population.
This study compared the 1-lead ECG intervals available via the Withings ScanWatch with the standard 12-lead ECGs in children and adolescents. Smart watch intervals have previously been shown to be accurate for adults. The heart rate measure was found to be reliable for children, The automated QTc interval was less reliable but can be improved with manual measurements. It is worth noting that the study used pediatric subjects rather than adapting adult research, as is often the case.
This study of 67,254 adults showed that 30% of adults do not get the recommended 7-9 hours of sleep per night, and that even those who did average 7-9 hours, 40% of the nights fell outside the range. Only 15% of participants slept 7-9 hours for at least 5 nights per week. In addition to the findings of irregular sleep, the study highlights the usefulness of the at home Withings Sleep for large-scale and/or longitudinal sleep studies.
As we close out a year of significant knowledge advancements, we look forward to seeing what the global healthcare research community has in store for 2025.
If you are conducting research that might benefit from Withings technology, please contact us at contact-pro@withings.com.
Interested in partnering with us?
Contact Us
[post_title] => Withings 2024 Year in Review: Research Highlights
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